RNA sequencing of decidua reveals differentially expressed genes in recurrent pregnancy loss

Differentially expressed genes (DEGs) in decidua from recurrent pregnancy loss (RPL) patients by utilizing RNA sequencing (RNA-seq) technology have not been well characterized before.In the current study, four RPL patients and three control women were recruited to conduct RNA-seq, and 153 genes comprising 69 were upregulated and 84 downregulated showed different expression levels between the health control and RPL groups. Overall design: Decidual tissues were collected during the procedure of dilation and curettage (D&C) after the ultrasonic diagnosis of fetal stopping developing in the uterus from four recurrent pregnancy loss patients. And decidua tissue from three control women was also collected during the procedure of D&C.