Gene Expression Profiling of SPOP Knocked Down Cell
收藏NIAID Data Ecosystem2026-04-29 收录
下载链接：
https://www.ncbi.nlm.nih.gov/sra/SRP110985
下载链接
链接失效反馈官方服务：
资源简介：
SPOP is one of the most frequent mutated genes in prostate cancer. In the current study, we identified CCNE1 as its substrate. SPOP directly interacts with CCNE1, poly-ubiquitinates CCNE1 in vivo and in vitro, and represses cancer-related phenotypes induced by CCNE1 expression. Thus, we reveal a new mechanism for SPOP in repressing prostate cancer tumorigenesis. Overall design: SPOP was knocked down by siRNA in DU145 and 769-P, the gene expression profile was studied by RNA sequencing
创建时间：
2021-07-25
