Parameters for G-protein dynamics.

Here, we varied the ratio of total number of G-protein (Gα2βγ+Gβγ) to the total number of receptors; for each case, the reaction rate constants of G-protein dynamics were estimated to match the half times of dissociation (t1/2,diss.) and reassociation (t1/2,reass.) from [17]. In reaction no. 2, RL is the total occupied receptors (H:C + L:C + S:C + PH:C + PL:C).