Gene expression study of human endometrial receptivity in IVF implantation failure patients undergoing ovarian stimulation

Endometrial receptivity on genomic level is one of the major cause of implantation failure in IVF patients with unexlained infertility and is a main obstacle in success of IVF. Gene expression profiles of implantation failure cases of unexplained infertility were compared with proven healthy oocyte donors as controls, both undergoing ovarian stimulation. The results provide additional information about gene expression profile related to endometrial receptivity in implantation failure cases especially under the influence of ovarian stimulation during IVF cycle. Total RNA isolated from endometrial tissue collected during implantation window from implantation failure cases with unexplained infertility (having normal hormones and endometrium with 8 mm and above, triple layered) were compared with oocyte donors as healthy proven fertile controls under the influence of long protocol of ovarian stimulation during IVF.