Circulating MicroRNAs as Potential Biomarkers of Early Vascular Damage in Vitamin D Deficiency, Obese, and Diabetic Patients

We report novel circulatory miRNAs biomarkers that are likely to provide specific non-invasive early diagnostic and prognostic tools for assessing vascular health. These comprise: miR-182-5p; miR-200c-3p; miR-199a-5p for vitamin D deficiency and obese patients, while miR-193-5p; miR-155-5p for vitamin D, obese and diabetic patients. This is the first paper to report those miRNAs and their target genes delineating their biological processes combined with clinical evidence of vascular stiffness using PWV (Pulse wave velocity) in middle aged Emirati population.