官方服务：
资源简介：
To reduce bystander editing.
应用场景：
创建时间：
2022-02-15
相关数据集
Expanding the genome-targeting scope and the site selectivity of high-precision base editors
Increased versatility of base editors
NIAID Data Ecosystem60
Expanded repertoire of RNA-editing-based detection for RNA binding protein interactions (4)
RNA binding proteins (RBPs) are key regulators of RNA processing and cellular function. Technologies to discover RNA targets of RBPs such as TRIBE (targets of RNA binding proteins identified by editin
NIAID Data Ecosystem40
A General Theoretical Framework to Design Base Editors with Reduced Bystander Effects
To assist in the design of these optimized editors, we propose a discrete-state stochastic approach to build an analytical model that explicitly evaluates the probabilities of editing the target base
NIAID Data Ecosystem20
Increasing efficiency and targeting scope of base editors through fusion of a single strand DNA binding protein domain
Cytidine base editors (CBEs) are powerful genetic tools which catalyze cytidine to thymidine conversion at specific genomic loci. However, the current CBEs are not very efficient especially for the pu
NIAID Data Ecosystem40
Enhanced base editing by co-expression of free uracil DNA glycosylase inhibitor
Even the latest generation of base editor (BE3) causes unwanted indels and non-C-to-T substitutions, compromising the fidelity of base editing outcome. Here we report a enhanced base editing system. T
NIAID Data Ecosystem30
