Generation of a long-acting fusion inhibitor against HIV-1
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Generation of a long-acting fusion inhibitor against HIV-1
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2024-10-16
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IgG Fc-binding motif-conjugated HIV-1 fusion inhibitor exhibits improved potency and in vivo half-life: Potential application in combination with broad neutralizing antibodies
The clinical application of conventional peptide drugs, such as the HIV-1 fusion inhibitor enfuvirtide, is limited by their short half-life in vivo. To overcome this limitation, we developed a new str
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Sensitivity of Human Immunodeficiency Virus Type 1 to the Fusion Inhibitor T-20 Is Modulated by Coreceptor Specificity Defined by the V3 Loop of gp120
T-20 is a synthetic peptide that potently inhibits replication of human immunodeficiency virus type 1 by interfering with the transition of the transmembrane protein, gp41, to a fusion active state fo
PubMed Central40
Gp41-targeting HIV-1 fusion inhibitors with hook-like Ile-Asp-Leu tail
Gp41-targeting HIV-1 fusion inhibitors with hook-like Ile-Asp-Leu tail Descriptor: Envelope glycoprotein gp160,gp41 CHR region, TRIS(HYDROXYETHYL)AMINOMETHANE Authors: Zhu, Y, Ye, S, Zhang, R. Deposit
Protein Data Bank Japan2024-03-20 更新30
Structure of gp41 T21/Cp621-652
Structure of gp41 T21/Cp621-652 Descriptor: ACETIC ACID, Envelope glycoprotein gp160, GLYCEROL Authors: Yao, X, Waltersperger, S, Wang, M, Cui, S. Deposit date: 2011-08-22 Release date: 2012-04-25 Las
Protein Data Bank Japan2024-11-06 更新50
Inhibitory activities of fusion inhibitors against divergent HIV-1 subtypes a .
Inhibitory activities of fusion inhibitors against divergent HIV-1 subtypesa.
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