Human GLS in complex with compound 12
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Human GLS in complex with compound 12 Descriptor: Glutaminase kidney isoform, mitochondrial, ~{N}-[5-[[(3~{R})-1-(5-azanyl-1,3,4-thiadiazol-2-yl)pyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]-2-phenyl-ethanamide Authors: Debreczeni, J.E. Deposit date: 2022-11-25 Release date: 2023-01-18 Last modified: 2024-06-19 Method: X-RAY DIFFRACTION (2.38 Å) Cite: Discovery of a Thiadiazole-Pyridazine-Based Allosteric Glutaminase 1 Inhibitor Series That Demonstrates Oral Bioavailability and Activity in Tumor Xenograft Models. J Med Chem, 62, 2019
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2022-11-25
