Synthesis of the Privileged 8‑Arylmenthol Class by Radical Arylation of Isopulegol
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资源简介：
Hydrogen atom transfer
(HAT) circumvents a disfavored Friedel–Crafts
reaction in the derivatization of the inexpensive monoterpene isopulegol.
A variety of readily prepared aryl and heteroaryl sulfonates undergo
a formal hydroarylation to form 8-arylmenthols, privileged scaffolds
for asymmetric synthesis, as typified by 8-phenylmenthol. High stereoselectivity
is observed in related systems. This use of HAT significantly extends
the chiral pool from the inexpensive monoterpene isopulegol.
创建时间：
2016-05-27
