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Bulk and single cell profing of CD45+ LSK cells collected from WT and TET2 deficient mice under normoxia and hypoxia (physioxia) conditions

NIAID Data Ecosystem2026-03-14 收录

造血干细胞缺氧响应

TET2表观遗传调控

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE192993 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2022-12-01

肥大细胞分化与增殖

TET2表观遗传调控

Dioxygenases of the TET family impact genome functions by converting 5-methylcytosine (5mC) in DNA to 5-hydroxymethylcytosine (5hmC). Here, we identified TET2 as a crucial regulator of mast cell diffe

NIAID Data Ecosystem70

TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic Activities.

肥大细胞分化

TET2表观遗传调控

Dioxygenases of the TET family impact genome functions by converting 5-methylcytosine in DNA to 5-hydroxymethylcytosine (5hmC), but their contribution to differentiation and function of immune cells i

NIAID Data Ecosystem30

Transcriptomes of CD34+ hematopoietic stem/progenitor cells (HSPCs) from myelodysplastic syndromes (MDS) patients cultured in normoxia or hypoxia.. Transcriptomes of CD34+ hematopoietic stem/progenitor cells (HSPCs) from myelodysplastic syndromes (MDS) patients cultured in normoxia or hypoxia.

骨髓增生异常综合征

造血干细胞缺氧响应

Three MDS patients (SF3B1mut -H662/H662/Q699) and three age-matched healthy donors were challenged in colony forming assay under normoxic (20% O2) and hypoxic (3% O2) conditions. RNA-sequencing was pe

NIAID Data Ecosystem20

Additional file 2 of miR-544 promotes maturity and antioxidation of stem cell-derived endothelial like cells by regulating the YY1/TET2 signalling axis

甲基化测序

TET2表观遗传调控

Additional file 1. The results of hMeDIP-Seq assay.

NIAID Data Ecosystem30

TET2 guards against unchecked BATF3-induced CAR T cell expansion [ATAC-seq]

CART细胞扩增调控

TET2表观遗传调控

Comparing genome accessibility profiles (ATACseq) of TET2 deficent hyper-proliferative CAR T cells and unedited CAR T cells Overall design: Unedited and TET2-edited human CAR T cells were sorted from

NIAID Data Ecosystem30

Bulk and single cell profing of CD45+ LSK cells collected from WT and TET2 deficient mice under normoxia and hypoxia (physioxia) conditions

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