Modulation of DNA Binding by Reversible Metal-Controlled Molecular Reorganizations of Scorpiand-like Ligands
收藏Figshare2016-02-20 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Modulation_of_DNA_Binding_by_Reversible_Metal_Controlled_Molecular_Reorganizations_of_Scorpiand_like_Ligands/2514247
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DNA interaction with scorpiand azamacrocycles has been achieved through modulation of their binding affinities. Studies performed with different experimental techniques provided evidence that pH or metal-driven molecular reorganizations of these ligands regulate their ability to interact with calf thymus DNA (ctDNA) through an intercalative mode. Interestingly enough, metal-driven molecular reorganizations serve to increase or decrease the biological activities of these compounds significantly.
创建时间：
2016-02-20
