Genetic Signatures from RNA sequencing of Pediatric Localized Scleroderma (LS) Skin

In this study, we explored the initial results of RNA transcriptomic expression between pediatric localized scleroderma skin tissue and healthy control skin, with a subanalyses of transcriptomic expression in different disease states. LS gene signatures compared to healthy controls showed a distinct expression of an inflammatory response gene signature (IRGS) composed of IFNγ, IFNα and TNFα associated genes. Comparision between localized scleroderma and healthy controls in bulk sequencing of the skin