Effectiveness of HIV Pre-Exposure Prophylaxis (PrEP): A Meta-Analysis of 100 Studies (2000–2025)

This document presents a comprehensive meta-analysis of 100 studies published between 2000 and 2025 on the effectiveness of HIV pre-exposure prophylaxis (PrEP). It synthesizes findings from randomized controlled trials and observational studies across diverse populations, including MSM, serodiscordant couples, people who inject drugs, and high-risk heterosexuals. The analysis highlights adherence as the most critical factor influencing PrEP efficacy, evaluates safety outcomes, and compares oral versus injectable PrEP regimens. Results confirm that PrEP is a safe, effective, and essential component of global HIV prevention strategies. Policy recommendations emphasize adherence support, equitable access, and integration into primary healthcare systems.