Predicting Pseudomonas aeruginosa susceptibility phenotypes from whole genome sequence resistome analysis

Frequent Pseudomonas aeruginosa antimicrobial resistance is driven by a complex repertoire of resistance phenotypes, resulting from both, mutation-driven and horizontally-acquired mechanisms. The objective of this work was to develop and validate a resistance genotype score, based on the analysis of the whole genome sequence resistome, to predict P. aeruginosa antimicrobial susceptibility phenotype.