SignaLink 3.0

SignaLink 3.0 is an integrated resource to analyze signaling pathway cross-talks, transcription factors, miRNAs and regulatory enzymes. Main features: - A signaling network resource with known and predicted information for human and model organisms - Manually curated dataset of major signaling pathways - including curated data from resources such as ACSN, InnateDB, Reactome and Signor - Extends pathways with integrated regulatory resources to contain pathway-specific transcription factors, miRNA, scaffolds and post translational modifying enzymes - Proteins are classified by pathway position (core/non-core) and function (ligand, receptor, mediator, etc.) - Signaling interactions are directed and labeled with PubMed IDs of the publications of experimental evidence - A multi-layered network structure allows the selection of user-specific details - Allows filtering based on tissue or sub-cellular localization - Supporting downloads in csv or psimi tab formatsSignaLink 3.0是一款用于解析信号通路串扰、转录因子、微小RNA（miRNA）及调控酶的整合型分析资源。核心功能如下： - 构建覆盖人类及模式生物的信号网络资源，收录已知及预测的信号相关信息 - 包含经人工审校的主流信号通路数据集，其数据源自ACSN、InnateDB、Reactome及Signor等权威资源 - 整合调控类数据库对通路进行扩展，涵盖通路特异性的转录因子、miRNA、支架蛋白及翻译后修饰酶 - 依据蛋白在通路中的位置（核心/非核心）及其功能（配体、受体、介质等）完成分类 - 信号交互均为有向交互，并标注了支撑实验证据的文献PubMed标识符 - 采用多层级网络结构，支持用户自定义选取所需的细节信息 - 支持基于组织或亚细胞定位的筛选操作 - 支持以csv或psimi tab格式下载数据

搜集汇总

背景与挑战

背景概述

SignaLink 3.0是一个整合资源，用于分析信号通路交叉对话、转录因子、miRNA和调控酶。其主要特点包括：提供人类和模式生物的信号网络资源，包含手动整理的主要信号通路数据集，并扩展了通路特异性转录因子、miRNA和翻译后修饰酶等调控信息；支持基于组织或亚细胞定位的过滤，以及多种格式的数据下载。