Supplementary Files

Supplementary Microsoft Excel files containing extended data that is referenced in the text. These include:File S1: Select proteins’ 30MY ERC lists, contains multiple-test corrected p-values. File S2: Pairwise ρ and unadjusted p-value 30MY ERC matrices for all proteins. File S3: Enrichment results for select top ERC protein sets. File S4: Zip file containing the mammalian time-scaled phylogeny and maximum likelihood protein trees in newick format. File S5: Table depicting the total number of taxa present for each protein’s sequence data, along with the number of taxa for which there are paralogy in the uncorrected and 30MY corrected data. File S6: Branch time to terminal branch rate correlation results for the protein set. File S7: Chi-squared test results for all proteins testing for whether there is an overrepresentation of rates below the regression line for short branches (<30MY). File S8: Branch time vs terminal branch rate residuals to branch time correlation results for the protein set. File S9: Wilcoxon matched signed-rank test significance values testing for branch adjustments following 20MY and 30MY adjustments. File S10: Coefficients for the select proteins used for the linear models containing ACE2 rate rank, Btime rate rank, and taxonomic orders as independent variables. File S11: 30MY-adjusted ERC comparisons within and between CORUM complex members.