Expression data that humanized anti-RGMa antibody treatment effect on blood-spinal cord barrier in mouse model of locally induced autoimmune encephalomyelitis

The aim of this study was to longitudinally evaluate the effect of anti-RGMa antibody on spinal cord pathology in a mouse model of experimental autoimmune encephalomyelitis. The effect of anti-RGMa antibody on accelerated blood-spinal cord barrier repair was revealed by high-field MRI. Immunohistochemical analysis and gene expression analysis were also used to confirm the effects. C57BL/6 mice were divided into three experimental groups: Naive, anti-RGMa antibody-treated, and isotype control antibody-treated. total RNA was isolated from the thoracic spinal cord of the three experimental groups (3 experimental groups x 5-6 mice = 17 mice in total).