Sequencing Data for "Unbiased RNA Degrader Identification (URID) Uncovers an LC3B-Recruiting Chimera for COL15A1 mRNA Degradation"

An RNA-binding fragment (F1) with a mapped transcriptome-wide binding profile was conjugated to the LC3B ligand ispinesib to generate the degrader F1-ispinesib. Integration of RNA-seq and Chemical Cross-Linking and Isolation by Pull-down combined with NGS Sequencing (Chem-CLIP-seq) data identified collagen type XV alpha 1 chain (COL15A1) mRNA as a target selectively degraded by F1-Ispinesib. Other full plasmid sequencing files are also included here.