Effect of SLC25A1 knockdown on chromatin accessibility during differentiation of human airway basal cells

To investigate the role of mitochondrial citrate export in differentiation of airway basal cells, we knocked down SLC25A1, the gene encoding mitochondrial citrate carrier. We then performed chromatin accessibility profiling analysis using data obtained from ATAC-seq of 5 donors at three time points. Overall design: Comparative chromatin accessibility profiling analysis of ATAC-seq data for human airway basal cells and its SLC25A1 knockdown derivative (shSLC25A1)