Rare coding variants identified in the 111 target candidate genes using whole exome sequencing in nine patients with suspected MODY.

aSIFT: − tolerated, + not tolerated/PolyPhen-2: − benign, + possibly damaging, ++ probably damaging/Align-GVGD: the Grantham variation (GV), and the Grantham deviation (GD) are combined to provide graded classifiers from most likely to interfere with function (class C65) to least likely (class C0).
bAllele frequencies from the interim analysis of phase I of the 1000 Genomes Project, 2010.08.04 sequence index, which included 629 samples (SNPs released in November 2010, indels released in February 2011).
Abbreviation: Chr, chromosome number; 1000 G, the 1000 Genomes Project; n.a, not analysed due to insufficient number of alignments to make prediction.