A Convenient Route to Enantiopure 3-Aryl-2,3-diaminopropanoic Acids by Diastereoselective Mannich Reaction of Camphor-Based Tricyclic Iminolactone with Imines
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https://figshare.com/articles/dataset/A_Convenient_Route_to_Enantiopure_3_Aryl_2_3_diaminopropanoic_Acids_by_Diastereoselective_Mannich_Reaction_of_Camphor_Based_Tricyclic_Iminolactone_with_Imines/2941141
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资源简介：
A novel and convenient route to the asymmetric synthesis of 2,3-diamino acids via Mannich reaction of iminolactones 1a and 1b with N-protected imines has been achieved in good yields (up to 95%) and high diastereoselectivity (dr: >99:1). Hydrolysis of the Mannich adducts under acidic conditions furnished the desired 3-aryl-2,3-diaminopropanoic acids in good yields (up to 85%) with excellent enantiomeric excesses (99% ee).
创建时间：
2016-02-27
