Additional file 1: of Exosomes derived from miR-92a-3p-overexpressing human mesenchymal stem cells enhance chondrogenesis and suppress cartilage degradation via targeting WNT5A

MiRNA expression profiles in exosomes before and after chondrogenic differentiation of MSCs. The expression profiles of miRNAs in exosomes before and after chondrogenic differentiation were detected using a miRNA microarray. SAM statistical software was used to identify differentially expressed miRNAs between undifferentiated MSC-Exos and chondro-differentiated MSC-Exos. Among the miRNAs that were consistently differentially expressed in all three paired samples, 36 were upregulated (fold change > 2) and 105 were downregulated (fold change <− 2) in chondro-differentiated MSC-Exos compared to levels in MSC-Exos. (XLSX 69 kb)