Therapeutic and safety outcomes of intracoronary nicardipine in coronary artery disease patients: a systematic review supplementary data

Aim: This systematic review aimed to shed light on the efficacy of intracoronary (IC) nicardipine in
treating no reflow with CAD undergoing revascularization. Methods: Literature search was performed
on databases with following eligibility criteria: adult patients with CAD; clinical trials or observational
studies; IC nicardipine as intervention; therapeutic and safety outcome reported. Results: A total of 1249
papers were yielded during the literature search. Of these, 11 studies were finalized for this systematic
review. Complete restoration of TIMI 3 flow was observed in 98.6% of the patients receiving IC nicardipine.
A significant increase in the CBF after infusion of IC nicardipine (p < 0.05) was also observed. Conclusion:
IC nicardipine significantly increases CBF and decreases coronary vascular resistance.