Gut Microbiota in Women with GDM has Potential Impact on Metabolism in Pregnant Mice and Their Offspring

Studies have shown that gestational diabetes mellitus (GDM) is closely related to abnormalities in the gut microbiota, and the offspring of these women have an increased risk of diabetes. There is no direct evidence of whether bacteria in women with GDM colonize the intestinal tract of offspring and cause hyperglycemia. In this fecal microbiota transplantation (FMT) pregnant mouse model study, Germ-free (GF) mice after FMT showed different colonization patterns of gut microbiota: Akkermansia and Faecalibacterium were significantly lower in GDM-FMT mice than the control group(Health-FMT), which may be related to the low content of short-chain fatty acids and naringenin in feces, and may also be related to hyperglycemia, inflammation, and liver steatosis. In addition, the influence of the gut microbiota continued on posterity. The relative abundance of Akkermansia and Parvibacter in the gut microbiota of the offspring of GDM-FMT mice is lower, but the relative abundance of Oscillibacter, Romboutsia, Harryflintia, etc. is higher, and this microbiota structure may be related to the higher blood glucose level and body weight in mice. Through this study, we made it clear that the gut microbiota of the offspring is greatly affected by the mother and provided evidence for the necessity of intervention for the intestinal flora in women with hyperglycemia during pregnancy.