Agreement between arterial and capillary pH, pCO2 and lactate in patients in the emergency department

We conducted a prospective monocentric study on a convenience sample of patients admitted to the ED from December 2017 to April 2018. Adults presenting to the ED for whom the treating clinician deemed necessary an arterial BGA were screened for inclusion if not pregnant. Screening was performed according to study personnel availability and overall workload. aimed for a standard error of the 95% limit of agreement of approximatively +/- 0.01.
Simultaneous arterial and capillary samples were drawn for BGA. Arterial BGA were sampled by direct arterial radial or femoral puncture using a pre-heparinized syringe (safe-PICO aspirator®, 1,7ml, Radiometer®). Capillary samples were obtained at patients’ finger using a contact-activated lancet (BD Microtainer®, Becton dickinson®) and collected through capillary tubes (safeCLINITUBES® 70µl, Radiometer®). Samples were analyzed with the same point of care BGA analyzer (ABL90 FLEX® Radiometer®). Analysis was not blinded, clinical information, index test results and reference standard results were available to the assessors of the reference standard.

本研究为前瞻性单中心研究，对2017年12月至2018年4月期间急诊科（ED）入院的患者进行了便利样本抽样。对那些治疗医生认为有必要进行动脉血气分析（BGA）的成年人进行了筛选，条件是不孕。筛选工作根据研究人员的可用性和整体工作量进行。旨在达到95%置信区间误差约为±0.01的标准。同时采集动脉和毛细血管样本进行BGA分析。动脉BGA通过使用预肝素化注射器（safe-PICO吸引器®，1.7ml，Radiometer®）进行直接动脉桡动脉或股动脉穿刺采集。毛细血管样本通过在患者手指处使用接触激活的采血针（BD Microtainer®，Becton dickinson®）获得，并通过毛细血管管（safeCLINITUBES® 70µl，Radiometer®）收集。样本使用同一台床旁BGA分析仪（ABL90 FLEX® Radiometer®）进行分析。分析过程未进行盲法，临床信息、指标测试结果和参考标准结果均可供参考标准评估者参考。