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Modulation of cell metabolic pathways and oxidative stress signaling contribute to acquired melphalan resistance in multiple myeloma cells

ChEBI2014-09-03 更新2026-07-21 收录

多发性骨髓瘤耐药机制

细胞代谢与氧化应激

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-60970 数据链接链接失效反馈

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Modulation of cell metabolic pathways and oxidative stress signaling contribute to acquired melphalan resistance in multiple myeloma cells

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创建时间：

2014-09-03

多发性骨髓瘤耐药机制

基因表达谱分析

1) We identified the genes whose expression was up- and down-regulated by the adhesion to bone marrow stromal cells in human multiple myeloma cell line RPMI8226. 2) We identified the genes whose expre

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ETV4-Dependent Transcriptional Plasticity Maintains MYC Expression and Results in IMiD Resistance in Multiple Myeloma [RNA-seq]

多发性骨髓瘤耐药机制

肿瘤转录组学

Immunomodulatory Drugs (IMiDs) are a backbone therapy for multiple myeloma (MM). Despite their efficacy, most patients develop resistance and the mechanism(s) are not fully defined. Here, we show that

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NPM1 mediated up – regulation of CXCR4 might drive bortezomib resistance in multiple Myeloma

多发性骨髓瘤耐药机制

NPM1基因

Bortezomib (BTZ) containing regimens induces significant antitumor response in multiple myeloma (MM) and are considered as the first-line treatment. However, resistance is still one of the unsolved pr

Figshare2025-10-25 更新20

Table_4_S100 Calcium Binding Protein Family Members Associate With Poor Patient Outcome and Response to Proteasome Inhibition in Multiple Myeloma.XLSX

多发性骨髓瘤耐药机制

S100蛋白家族功能研究

Despite several new therapeutic options, multiple myeloma (MM) patients experience multiple relapses and inevitably become refractory to treatment. Insights into drug resistance mechanisms may lead to

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Gene expression profile of hyaluronan-induced cell clusters in multiple myeloma. Gene expression profile of hyaluronan-induced cell clusters in multiple myeloma

多发性骨髓瘤耐药机制

基因表达谱分析

We identified the changes in gene expression profile in hyaluronan-induced spheroids to elucidate the mechanisms of drug resistance of extramedullary disease in multiple myeloma. Overall design: We cu

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Modulation of cell metabolic pathways and oxidative stress signaling contribute to acquired melphalan resistance in multiple myeloma cells

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