Mouse blood gene expression after administration of 137 Cesium

In the current study, we investigated the gene expression response of blood cells of mice that were injected with variable amounts of 137Cs We isolated total RNA from peripheral blood from mice with 0 (control), 158, 191, 215 and 259 uCi cesium source amount on days 2, 3, 5, 7 and 14 days after injection. Using Agilent Mouse Whole Genome microarrays, we identified x genes that were significantly differentially expressed across the 14-day time course of this study. We identified common biological functions affected that persisted across the 14-day study. Radiation induced gene expression was measured at 2, 3, 5, 7 and 14 days after injection. There were a minimum of 6 replicates per group in this study.