Functional screen for novel regulators of murine hematopoietic stem cell in vivo repopulating activity

ChEBI2015-07-01 更新2026-07-12 收录

造血干细胞调控

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数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-63830 数据链接链接失效反馈

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资源简介：

Functional screen for novel regulators of murine hematopoietic stem cell in vivo repopulating activity

创建时间：

2015-07-01

ERG promotes the maintenance of hematopoietic stem cells by restricting their differentiation

造血干细胞调控

转录因子功能分析

To investigate the role of the transcription factor ERG in hematopoiesis we generated Erg heterozygous knockout and conditional Erg knockout mice. We found that several hematopoietic cell types were d

NIAID Data Ecosystem60

In Vivo Analysis of Retroviral Enhancer Mutations in Hematopoietic Cells: SP1/EGR1 and ETS/GATA Motifs Contribute to Long Terminal Repeat Specificity

造血干细胞调控

逆转录病毒增强子功能

The objective of this work was to identify, in the context of chromosomally integrated DNA, the contribution of defined transcription factor binding motifs to the function of a complex retrovirus enha

PubMed Central40

Maintenance of haematopoietic stem cells by tyrosine-unphosphorylated STAT5 and JAK inhibition - STAT5 deficient HSPCs (LK). Maintenance of haematopoietic stem cells by tyrosine-unphosphorylated STAT5 and JAK inhibition - STAT5 deficient HSPCs (LK)

造血干细胞调控

JAK-STAT信号通路

Adult haematopoietic stem cells (HSCs) are responsible for the lifelong production of blood and immune cells and must respond to extracellular cues including cytokines. The JAK/STAT pathway is a highl

NIAID Data Ecosystem20

Convergence of Hypoxia and TGFβ Pathways on Cell Cycle Regulation in Human Hematopoietic Stem/Progenitor Cells

造血干细胞调控

缺氧响应机制

Although it has been shown that HIF1 and 2 fulfill essential roles within the hematopoietic system and in the regulation of HSC fate, little is currently known about the specific mechanisms that are i

NIAID Data Ecosystem50

Musashi 2 is a regulator of the hematopoietic stem cell compartment identified by a retroviral insertion screen and knockout mice

造血干细胞调控

基因功能研究

Musashi 2 is a regulator of the hematopoietic stem cell compartment identified by a retroviral insertion screen and knockout mice

ChEBI2011-05-21 更新20