Telomere dysfunction cooperates with epigenetic alterations to impair murine embryonic stem cell fate commitment

This study demonstrates a specific cooperativity between perturbations in histone methylation and eroded telomeres to destabilize the differentiation of murine embryonic stem cells. Murine embryonic stem cells of two different genotypes (WT or Tert-/-) were subjected to differentiation, and treated with compounds that modulated histone H3K27 tri-methylation to assess their impact upon the differentiation response