Value-related learning in the olfactory bulb occurs through pathway-dependent peri-somatic inhibition of mitral cells

Associating values to environmental cues is a critical aspect of learning from experiences, allowing animals to predict and maximise future rewards. Value-related signals in the brain were once considered a property of higher sensory regions, but their wide distribution across many brain regions is increasingly recognised. Here, we investigate how reward-related signals begin to be incorporated, mechanistically, at the earliest stage of olfactory processing, namely, in the olfactory bulb. In head-fixed mice performing Go/No-Go discrimination of closely related olfactory mixtures, rewarded odours evoke widespread inhibition in one class of output neurons, that is, in mitral cells but not tufted cells. The temporal characteristics of this reward-related inhibition suggest it is odour-driven, but it is also context-dependent since it is absent during pseudo-conditioning and pharmacological silencing of the piriform cortex. Further, the reward-related modulation is present in the somata but..., , , # **Value-related learning in the olfactory bulb occurs through pathway-dependent peri-somatic inhibition of mitral cells**

**Description of the data and file structure**

Data contained here are the individual data points plotted in the main figures of the manuscript currently under consideration at PLOS Biology (DOI to be added here upon acceptance/publication).

Data and file structure:

Individual data points on scatter are available in double-precision numeric arrays (both .mat and .csv formats).

Common abbreviations:

* MC: Mitral cells
* TC: Tufted cells
* ROI: region of interest
* sPlus: Rewarded trials (S+)
* sMin: Unrewarded trials (S-)
* ΔF/F: Normalized calcium fluorescence (see Methods)
* CaData: Calcium data (reported in ΔF/F)
* exc: excitatory
* inh: inhibitory

 

**Materials and Methods**

*Animals*

Tbx21-Cre (doi: 10.1038/nn.3407), B6J.Cg-Gt(ROSA)26Sortm95.1(CAG- GCaMP6f)Hze/MwarJ, also known as Ai95D (), and Ai14 (doi: 133-140. 10.1038/nn.2467 ) m...