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The E3 ligase HRD1 enhances plant antiviral immunity by targeting viral movement proteins

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Guo et al. report that the ERAD-associated E3 ligase NbHRD1 is an important antiviral component directly targeting triple gene block (TGB) movement proteins of plant viruses. NbHRD1 triggers the ubiquitination and 26S proteasome-mediated degradation of TGB proteins, thereby inhibiting virus infection.

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2025-02-18
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