Supplementary Tables 1-9 from Exome-Scale Discovery of Hotspot Mutation Regions in Human Cancer Using 3D Protein Structure

Table S1: Hotspot regions identified by 3D HotMAPS and overlap with 1D HotMAPS algorithm. Table S2: Tumor-type specific hotspot regions identified by 3D HotMAPS, overlap with 1D HotMAPS, and charactersitic features with naïve bayes score. Table S3: Sample and coverage information for missense mutations mapping onto protein structures or models. Table S4: Genes with HotMAPS regions identified in TCGA tumor types without previous literature support. Table S5: Hotspot regions identified by the 1D algorithm only utilizing primary sequence. Table S6: Tumor-type specifc hotspot regions identified by the 1D algorithm only utilizing primary sequence. Table S7: Residues in 3D HotMAPS regions that overlap with UniProtKB annotations. Table S8: Contigency table of hotspot residues at protein-protein interfaces versus other mutated residues. Table S9: Blacklisted residues that have ambiguous mappings caused by tBLASTn.