Dexamethasone effect on gene expression in human pancreatic islets and human pancreatic EndoC-ßH1 cells

To investigate the glucocorticoid-mediated transcriptomic changes in human pancreatic islets and the human insulin-secreting EndoC-ßH1 cells in order to uncover genes and molecular pathways involved in ß-cell steroid stress-response processes. Overall design: Comparative gene expression profiling analysis of human pancreatic islets (n=4 donors) and EndoC-ßH1 cells (n=4 biological replicates) after high-dose dexamethasone treatment (2 µ?)