Efficacy of reduction (in %) at year 90 in males and females with OA treated with UC-II and fisetin (<i>D</i>).

UC-II is administered daily for 6 months, followed by a 6-month break, in repeated cycle. Fisetin is taken during the first two days of each month and repeated monthly. Treatment begins at various times (Treatment Initiation) and ends at different times (Endtime).