Mean within and between individual synonymous and nonsynonymous rate for HIV and HCV*.

*dN and dS computed using the Modified Nei and Gojobori method (MEGA v4). Intra-individual values for acute infection cohorts and inter-individual values for chronic infection cohorts. Two time-points used for analysis - 1st time-point (T0) within 3–4 months of infection and 2nd time-point closest time-point to 1 year from T0. n = number of subjects.∧HIV sequences from [14]. dS-dN summed for all subjects and then divided by number of total subjects (for acute subjects). HCV genotype 1a sequences from cross-sectional chronic cohort in [22]. HIV clade B sequences from cross-sectional chronic cohort in [29].