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Promoter DNA methylation couples genome-defense mechanisms to epigenetic reprogramming in the mouse germline (part 2)

ChEBI2012-07-31 更新2026-07-21 收录

表观遗传重编程

细胞DNA甲基化

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-38306 数据链接链接失效反馈

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资源简介：

Promoter DNA methylation couples genome-defense mechanisms to epigenetic reprogramming in the mouse germline (part 2)

应用场景：

创建时间：

2012-07-31

精原干细胞多能性转化

表观遗传重编程

Mammalian spermatogonial stem cells (SSCs) spontaneously convert to multipotent adult spermatogonial-derived stem cells (MASCs) during in vitro expansion. Here, we examine the epigenetic signature of

NIAID Data Ecosystem90

Aberrant Methylated DNA Regions Lead to Low Activation of CD4+ T Cells with a Consequent Imbalance of the Th1/Th2 Polarization in IgA Nephropathy Patients

IgA肾病机制

细胞DNA甲基化

To investigate alterations in the DNA methylation of CD4+ T cells in IgA nephropathy (IgAN), we performed an initial whole-genome DNA methylation screening on CD4+ T cells isolated from 6 IgAN patient

NIAID Data Ecosystem70

Active and Passive Demethylation of Male and Female Pronuclear DNA in the Mammalian Zygote

受精卵DNA去甲基化

表观遗传重编程

The epigenomes of mammalian sperm and oocytes, characterized by gamete-specific 5-methylcytosine (5mC) patterns, are reprogrammed during early embryogenesis to establish full developmental potential.

NIAID Data Ecosystem50

DNA methylation status of myelinating Schwann cells during development and in diabetic neuropathy [Gene Expression Array: GNMT mice]

细胞DNA甲基化

神经病变机制

DNA methylation is a key epigenetic regulator of mammalian embryogenesis and somatic cell differentiation. Using high-resolution genome-scale maps of methylation patterns, we show that the formation o

NIAID Data Ecosystem70

Ago1 controls myogenic differentiation by regulating eRNA mediated CBP guided epigenome reprogramming

肌肉分化调控

表观遗传重编程

The role of Argonaute (Ago) proteins in post-transcriptional gene silencing in the cytoplasm is well characterized. However, its nuclear function still remains elusive. In this work, we investigated t

NIAID Data Ecosystem50

Promoter DNA methylation couples genome-defense mechanisms to epigenetic reprogramming in the mouse germline (part 2)

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