ReMap

ReMap is a large scale integrative analysis of DNA-binding experiments for Homo sapiens, Mus musculus, Drosophila melanogaster and Arabidopsis thaliana transcriptional regulators. The catalogues are the results of the manual curation of ChIP-seq, ChIP-exo, DAP-seq from public sources (GEO, ENCODE, ENA). ReMap (https://remap.univ-amu.fr) aims to provide manually curated, high-quality catalogs of regulatory regions resulting from a large-scale integrative analysis of DNA-binding experiments in Human, Mouse, Fly and Arabidopsis thaliana for hundreds of transcription factors and regulators. In this 2022 update, we have uniformly processed >11 000 DNA-binding sequencing datasets from public sources across four species. The four regulatory catalogs are browsable through track hubs at UCSC, Ensembl and NCBI genome browsers. Finally, ReMap 2022 comes with a new Cis Regulatory Module identification method, improved quality controls, faster search results, and better user experience with an interactive tour and video tutorials on browsing and filtering ReMap catalogs.ReMap是针对智人（Homo sapiens）、小家鼠（Mus musculus）、黑腹果蝇（Drosophila melanogaster）与拟南芥（Arabidopsis thaliana）转录调控因子DNA结合实验的大规模整合分析数据库。该目录集源自公共数据源（GEO、ENCODE、ENA）中ChIP-seq、ChIP-exo、DAP-seq实验的人工整理与注释。ReMap（https://remap.univ-amu.fr）旨在针对数百种转录因子与调控因子，通过对人类、小鼠、果蝇及拟南芥的DNA结合实验开展大规模整合分析，进而提供经人工整理注释的高质量调控区域目录集。在本次2022年更新版本中，研究团队已统一处理了来自四大物种公共数据源的逾11000条DNA结合测序数据集。上述四大调控目录集可通过UCSC、Ensembl及NCBI基因组浏览器的track hubs进行浏览。此外，ReMap 2022版新增了顺式调控模块（Cis Regulatory Module）识别方法，优化了质量控制流程，提升了搜索响应速度，并通过交互式导览以及浏览、筛选ReMap目录集的视频教程进一步优化了用户体验。

搜集汇总

背景与挑战

背景概述

ReMap是一个大规模整合分析数据库，通过手动整理公共来源的DNA结合实验数据（如ChIP-seq、ChIP-exo和DAP-seq），为人类、小鼠、果蝇和拟南芥提供高质量的转录因子调控区域目录。该数据集支持在多个基因组浏览器中浏览，并包含2022年更新，涵盖了超过11,000个测序数据集，改进了质量控制、搜索功能和用户体验。