Condensin-Driven Remodeling of X-Chromosome Topology during Dosage Compensation
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This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series
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2014-07-23
相关数据集
ChIP-chip analysis of Dosage Compensation complex members SDC-3 and DPY-27 in C elegans wild type embryos.
Among organisms with chromosome-based mechanisms of sex determination, failure to equalize expression of X-linked genes between the sexes is typically lethal. In C. elegans, XX hermaphrodites halve tr
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Ectopically expressed MSL2 females compared with normal females
We used H83M2 P element to ectopically expressed MSL2 protein in females to test if the novel formed MSL complex is the directly reason of dosage compensation Overall design: Compare the MSL2 females
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Examination of DPY-30, DPY-27, SDC-3, DPY-26, MIX-1, SMC-4, ASH-2, RNA Polymerase II binding in wild type and DCC mutant embryos
Here we exploit the essential process of X-chromosome dosage compensation to elucidate basic mechanisms that control the assembly, genome-wide binding, and function of gene regulatory complexes that
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Binding of an X-specific condensin correlates with a reduction in active histone modifications at gene regulatory elements. Binding of an X-specific condensin correlates with a reduction in active histone modifications at gene regulatory elements
Condensins are evolutionarily conserved protein complexes that are required for chromosome segregation during cell division and genome organization during interphase. In C. elegans, a specialized cond
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Sequence variation within similar cis-elements promotes context-specific functions of two Drosophila GA-binding transcription factors (ChIP-seq data set)
A key model for understanding how large transcription complexes are targeted is the Drosophila dosage compensation system in which the Male-Specific Lethal (MSL) transcription complex specifically ide
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