PREPRATON AND CHARACTERIZATION OF STEROID-LINKED DERIVATIVES AS ANTICANCER AGENTS"

of a variety of regulatory function such as ovulation, development of corpusluteum, and maintenance of<br>uterine quiescence during pregnancy. It is also involved in proliferation and differentiation of mammary<br>glands. The biological activity of progesterone is mediated by the progesterone receptor [PR], a member<br>of the large gene family of nuclear receptors, which induces a cascade of transcriptional events after<br>binding with the hormone. PR contains three functional domains including the N-terminus, a centrally<br>located DNA binding domain (DBD) and C-terminal ligand binging domain (LBD) respectively. The<br>binding of progesterone induces of conformational change in PR that promotes dissociation from a<br>multi-protein complex followed by homo dimerization and binding to specific progesterone response<br>elements (PRE) within the promoter genes. The hormone activated PR recruits co-activators throug