Additional file 6 of Single-cell analysis defines highly specific leukemia-induced neutrophils and links MMP8 expression to recruitment of tumor associated neutrophils during FGFR1 driven leukemogenesis

Supplementary Material 6: Supplemental Fig. 6.Clinical relevance of target genes in ALL and KIRC. Kaplan-Meier analysis of the Pediatric Acute Lymphoid Leukemia (ALL) in Phase II clinical trial cohort shows decreased survival in patients with high-level expression of MMP8 (A, left) and MMP9 (A, right). In an analysis of KIRC patient data in the TCGA dataset using the TIMER2.0 algorithm, there is a significant positive correlation between FGFR1expression and tumor neutrophil infiltration levels (B, left). Similarly, a significant positive correlation between IRAK1expression and tumor neutrophil infiltration levels is also detected in this data set (B, right). Kaplan-Meier analysis for IRAK1 expression levels in KIRC patients (C) shows poorer survival in patients expressing high levels of IRAK1.