RNA-seq of AML cells in control and abemaciclib-treated groups.

NIAID Data Ecosystem2026-05-01 收录

急性髓系白血病药物研究

CDK4

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https://www.ncbi.nlm.nih.gov/sra/SRP333815 数据链接链接失效反馈

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RNA-seq analysis was performed to compare regulated pathways between control groups and abemaciclib-treated groups.

创建时间：

2023-07-09

RNA-seq transcriptome analyses in T47D cells treated with ActA and Palbociclib.

癌症信号通路

CDK4

We performed SMAD2 ChIP-seq analysis in T47D cells with/without Palbociclib treatment. To validate whether the changes in SMAD2 binding to the genome indeed resulted in changes in target gene expressi

NIAID Data Ecosystem30

Gene expression analysis in AML systems after 6 hours of HDACi treatments. Homo sapiens

急性髓系白血病药物研究

去乙酰酶研究

K562, U937 and NB4 AML cell lines were treated with 2 HDACi, MS-275 and SAHA, and gene expression profiles were analysed to 6-hours treatments. The analysis revealed commonly regulated genes in the 3

NIAID Data Ecosystem20

DHODH in complex with Ligand 26

药物靶点结构解析

急性髓系白血病药物研究

DHODH in complex with Ligand 26 Descriptor: (2P,6P)-6-[4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-7-fluoro-2-(2-methylphenyl)-4-[(2R)-1,1,1-trifluoropropan-2-yl]isoquinolin-1(2

Protein Data Bank Japan2024-07-24 更新00

Discovery of FLT3-ITD Inhibitor Clifutinib: A Novel Biphenylacetylene Urea Derivative in Clinical Trials for the Treatment of Relapsed/Refractory FLT3-ITD + Acute Myeloid Leukemia

FLT3靶向治疗

急性髓系白血病药物研究

Internal tandem duplication (ITD) mutations of FLT3 (FLT3-ITD) are a promising target for patients with acute myeloid leukemia (AML), given that they have been identified in the majority of AML patien

NIAID Data Ecosystem20

Discovery of a Potent FLT3 Inhibitor (LT-850-166) with the Capacity of Overcoming a Variety of FLT3 Mutations

FLT3突变抑制剂

急性髓系白血病药物研究

Secondary mutations of FLT3 have become the main mechanism of FLT3 inhibitor resistance that presents a significant clinical challenge. Herein, a series of pyrazole-3-amine derivatives were synthesize

NIAID Data Ecosystem10

RNA-seq of AML cells in control and abemaciclib-treated groups.

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