The MD Anderson Colorectal Cancer Case Control Study

Colorectal cancer (CRC) is the second leading cause of cancer-related deaths in the US. Driven by common disease common variants hypothesis, genome-wide association studies only identified a number of common susceptibility loci that explained a small portion of CRC heritability. We conducted a case-control study using whole exome sequencing to identify rare genetic variants with intermediate effect size that predispose individuals to colorectal cancer.]]>
We conducted gene-based analyses for 2161 colorectal cancer cases and 3216 cancer-free controls of European ancestry using VAAST 2.0.This study includes 2161 cases with a primary colorectal cancer recruited at the University of Texas MD Anderson Cancer Center (MDA) and 3216 cancer-free controls recruited at MDA, the University of Utah School of Medicine, Duke University, and H. Lee Moffitt Cancer Center & Research Institute All controls have no prior history of cancer (with the exception of non-melanoma skin cancer) The controls from the University of Utah had no known first-degree relative with a history of cancer (with the exception of non-melanoma skin cancer) and no known second-degree relative with a history of melanoma]]>