Adverse Outcome Pathway on Deposition of Energy Leading to Occurrence of Bone Loss
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The present Adverse Outcome Pathway (AOP) describes the linkage between bone loss and the deposition of energy by radiation, a prototypic stressor relevant to spaceflight and radiotherapy. The initial ionization events cause oxidative stress, defined as an imbalance between oxidants and antioxidants, leading to oxidation of signaling proteins...
