Time resolved protein structures with 1000 Hz X-ray pulses in the 10-100us time range
收藏DataCite Commons2024-09-23 更新2025-04-15 收录
下载链接:
https://doi.esrf.fr/10.15151/ESRF-ES-1835728188
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资源简介:
.A group which has pioneered work at Free Electron Lasers for time resolved structural work on proteins we are interested to understand biologic processes from the structural point of view like Enzymology and Light driven reactions like photosynthesis or light triggered reactions of eg cytochrome c oxidase. From health science we try understanding the binding of drugs to fight cancer and the mechanism of Nendo U one of the proteins which gets expressed during Covid infection, this virus specific protein cuts off the poly U end from RNA. A targeted inhibition or suppression of the Nendo U would support the natural immune answer to fight Covid and similar viruses.
The bromodomains are involved in the regulation of various human cancers. We have proteins of several bromodomains to study potential drug ligands with nanomolar KD in their time resolved binding.
提供机构:
European Synchrotron Radiation Facility
创建时间:
2024-09-23



