IC50 of 2-H and lidocaine applied to hNav1.2 and hNav1.6 ion channels.
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Values are the mean IC50± SEM. n = 6 in all cases. 2-H and lidocaine both blocked the two channels that we tested. In the tonic experiments, 2-H was 3.97 (for hNav1.2) and 2.82 (for hNav1.6) times less active than lidocaine. In the phasic experiments, 2-heptanone was 7.50 (for hNav1.2) and 7.57 (for hNav1.6) times less active than lidocaine. The exposure time for 2-H was limited to 3 min.
创建时间：
2015-12-02
