ERAP1 in complex with (3R,4R)-1-[3-cyano-6-(cyclopropylamino)pyridin-2-yl]-4-(propan-2-yl)pyrrolidine-3-carboxylic acid

ERAP1 in complex with (3R,4R)-1-[3-cyano-6-(cyclopropylamino)pyridin-2-yl]-4-(propan-2-yl)pyrrolidine-3-carboxylic acid Descriptor: (3~{R},4~{R})-1-[3-cyano-6-(cyclopropylamino)pyridin-2-yl]-4-propan-2-yl-pyrrolidine-3-carboxylic acid, 1,2-ETHANEDIOL, Endoplasmic reticulum aminopeptidase 1, ... Authors: Rowland, P. Deposit date: 2025-11-27 Release date: 2026-07-08 Last modified: 2026-07-22 Method: X-RAY DIFFRACTION (1.73 Å) Cite: Discovery of an Orally Available Potent ER Aminopeptidase 1 (ERAP1) Inhibitor That Enhances Antitumor Responses and Limits Inflammatory Autoimmunity In Vivo . J.Med.Chem., 69, 2026