Genes that displayed enhanced connectivity in epileptic vs. normal neurons.

The top twenty genes that displayed the largest differences in connectivity between gene expression networks in epileptic and normal neurons. Three datasets were used to determine whether genes within the blue module displayed enhanced connectivity when compared to normal neuronal gene expression, including the Agilent data from the current study, a study of gene expression within normal neuronal sub-types [36], and a study of gene expression from the non-epileptic dentate gyrus [37]. Equivalent modules were identified in each dataset, and the connectivity (kME) for genes that had probes targeting the same exon was compared in all modules. The values of connectivity are displayed in the table for the most differentially connected genes.