Structure of full-length SMC and rearrangements required for chromosome organization

NIAID Data Ecosystem2026-03-10 收录

染色体构象调控

SMC蛋白功能

数据链接：

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资源简介：

In vitro biochemical assay, high throughput crosslinking screen, chromatin immunoprecipitation

创建时间：

2017-06-18

Transfer RNA Genes Affect Chromosome Architecture and Function [ChIP-seq]

染色体构象调控

tRNA基因

In this study, we investigated the role of tranfer RNA genes (tDNAs) in genome organization and nuclear function by generating a chromosome lacking all its tDNAs. Our analyses of this tDNA-less chromo

NIAID Data Ecosystem90

The non-canonical SMC protein SmcHD1 antagonises TAD formation on the inactive X chromosome (Repli-seq)

X染色体失活

SMC蛋白功能

In this study we investigate the role of the non-canonical SMC family protein, SmcHD1in the X inactivation. Allele-specific repli-seq experiments were done in wild-type and SmcHD1mut (SmcHD1 null Momm

NIAID Data Ecosystem60

Genome-wide binding of condensin II and TFIIIC upon respective knockdown of a TFIIIC and condensin II subunit

condensinII与TFIIIC互作

染色体构象调控

Condensin complexes are highly conserved for chromosome compaction to ensure their faithful segregation in mitosis. However, little is known about the role of condensin complexes in interphase. Conden

NIAID Data Ecosystem40

Genome organization controls transcriptional dynamics during development. Genome organization controls transcriptional dynamics during development

发育转录动力学

染色体构象调控

Past studies offer contradictory claims for the role of genome organization in the regulation of gene activity. Here, we show through high-resolution chromosome conformation analysis that the Drosophi

NIAID Data Ecosystem70

A boundary-defining protein facilitates megabase-scale regulatory chromosomal loop formation in Drosophila neurons

染色体构象调控

神经元基因表达

Meta-loops are large chromosomal loops that connect specific neuronal genes with non-coding DNA elements, enabling megabase-range regulation of gene transcription in fly neurons. To reveal how highly

NIAID Data Ecosystem50

Structure of full-length SMC and rearrangements required for chromosome organization

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