Whole genome metagenomic analysis of the gut microbiome in HIV-1 infected individuals on antiretroviral therapy

Gut microbiome plays a significant role in HIV-1 immunopathogenesis as well as in HIV-1-associated complications. Previous studies have mostly been based on 16S rRNA gene amplicon sequencing, which is limited in taxonomic resolution at bacterial genus level at best, and inferred functionality. In this study, we performed Shotgun metagenome sequencing in HIV-1 infected individuals on antiretroviral therapy.