A549_SyntheticLethal

Synthetic lethal networks for A549 cells. Circles indicate TSG, squares druggable targets, squares outlined in bold indicate FDA approval of drug targeting that gene. Color of node indicates single gene knockout fitness effect, red: positive fitness effect, blue: negative fitness effect. Previously reported interactions are indicated as red edges, and interactions validated in drug-drug assays in this study are shown in green. Black edges were identified in multiple cell lines in this study.